Nanoloom

DeviceNanoLoom is an imaging-based platform designed to advance drug discovery and development, by enabling direct observation of DNA-protein interactions at the single-molecule level.

Compatible

Designed to seamlessly integrate with commercial microscopes.

Reliable

Reproducible protocols have been optimized step by step to ensure consistency and rapid results.

Efficient

Operates using small volumes and low flow rates, minimizing sample waste.

Affordable

Priced reasonably to ensure accessibility to a wide range of researchers and scientists.

Single-molecule (SM) approaches provide critical insight into the kinetics of DNA-protein binding, and unbinding events, by tracking protein dynamics on DNA. Widely applied within academic research to the study of DNA replication, transcription, repair, and editing, SM offers a powerful experimental link between molecular structure and function.

To overcome these limitations, 1NA has built upon DNA Curtains technology, developed by Professor Greene at Columbia University. This technology involves using nanofabricated barriers within a microfluidic device to align thousands of DNA molecules simultaneously. By integrating this with NanoLoom, we enable high-resolution visualization of protein dynamics on DNA, allowing for rapid, direct assessment of molecular interactions. This significantly enhances the speed and accuracy of drug development research.