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Goal Accelerate the adoption of single-molecule techniques for drug development.

Background

Single-molecule techniques provide unparalleled insight into molecular interactions between proteins and DNA. These techniques hold tremendous promise for drug discovery by enabling high-resolution studies at the molecular level.

The Challenge

Despite their potential, single-molecule techniques face inherent throughput limitations that cannot be overcome by automation or faster analysis alone.

Removing key barriers using semiconductor technology.

Technology

The NanoLoom chip uses nanofabrication  to arrange individual DNA molecules in a microfluidic flow cell. This design boosts measurement throughput by orders of magnitude, unlocking the true power of single-molecule imaging.

Technology

Biotech

Quality control and optimization of the molecular biology in diagnostic kits and research.

Pharma

Drug development for cancer, antibiotic resistance, dementia, and rare diseases.

Agriculture

Development of pesticides and gene-modifying agents. Development of genetic variants to increase yields.

Military

Pandemic preparedness and biosecurity.

Beyond SequencingComparable to DNA sequencing in complexity, technological challenges, and impact. While sequencing focuses on DNA mutations, NanoLoom analyses DNA-protein interactions.

NanoLoom

NanoLoom chips are compatible with most commercially available fluorescent microscopes, and liquid handling systems. With the provided reagents and our on-site user training, you can start your first experiment within hours.

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Collaborations

Partner with us to validate NanoLoom’s technology for drug discovery. Accelerate breakthroughs in novel therapies targeting DNA processing proteins, and gain early access to high throughput single-molecule solutions.

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The technique developed by 1NA, combined with fluorescence microscopy, provides high-throughput data of proteins interacting with DNA. Our group is focusing on mitochondrial dysfunctions, where this technique will be our tool of choice for screening drugs targeting the mitochondrial replication machinery.

Prof. Géraldine Farge

at Université Clermont Auvergne